Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy.

@article{Crittenden2009DysregulationOC,
  title={Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy.},
  author={Jill R Crittenden and Ippolita Cantuti-Castelvetri and Esen Saka and Christine E. Keller-McGandy and Ledia F. Hern{\'a}ndez and Lauren R. Kett and Anne B. Young and David G Standaert and Ann M. Graybiel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 8},
  pages={2892-6}
}
Voluntary movement difficulties in Parkinson's disease are initially relieved by l-DOPA therapy, but with disease progression, the repeated l-DOPA treatments can produce debilitating motor abnormalities known as l-DOPA-induced dyskinesias. We show here that 2 striatum-enriched regulators of the Ras/Rap/ERK MAP kinase signal transduction cascade, matrix-enriched CalDAG-GEFI and striosome-enriched CalDAG-GEFII (also known as RasGRP), are strongly and inversely dysregulated in proportion to the… CONTINUE READING

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