Dysregulation of Anti-Inflammatory Annexin A1 Expression in Progressive Crohns Disease

  title={Dysregulation of Anti-Inflammatory Annexin A1 Expression in Progressive Crohns Disease},
  author={Angela Aparecida Servino Sena and Irina B Grishina and Anne Thai and Larissa Goulart and Monica Macal and Anne N. Fenton and Jay Y. Li and Thomas Prindiville and S{\^o}nia Maria Oliani and Satya Dandekar and Lu{\'i}z Ricardo Goulart and Sumathi Sankaran-Walters},
  booktitle={PloS one},
BACKGROUND Development of inflammatory bowel disease (IBD) involves the interplay of environmental and genetic factors with the host immune system. Mechanisms contributing to immune dysregulation in IBD are not fully defined. Development of novel therapeutic strategies is focused on controlling aberrant immune response in IBD. Current IBD therapy utilizes a combination of immunomodulators and biologics to suppress pro-inflammatory effectors of IBD. However, the role of immunomodulatory factors… CONTINUE READING
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