Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas.

@article{Chen2010DysregulationO,
  title={Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas.},
  author={Lei Chen and Liang Hu and Liang Li and Yuan Liu and Qian-qian Tu and Yan-xin Chang and He-xin Yan and Meng-chao Wu and Hong-yang Wang},
  journal={Frontiers of medicine in China},
  year={2010},
  volume={4 4},
  pages={399-411}
}
β-catenin is a key molecule involved in both cell-cell adhesion and Wnt signaling pathway. In our study, we found that, in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitis B virus (HBV) X gene encoded protein, which is essential for HBV infectivity and is a potential cofactor in viral carcinogenesis. The expression… CONTINUE READING