Dysregulated sphingolipid metabolism in endometriosis.

  title={Dysregulated sphingolipid metabolism in endometriosis.},
  author={Yie Hou Lee and Chin Wen Tan and Abhishek Venkatratnam and Chuen Seng Tan and Liang Cui and Seong Feei Loh and Linda Griffith and Steven R Tannenbaum and J. K. Y. Chan},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={99 10},
BACKGROUND In endometriosis, the establishment and subsistence of ectopic lesions outside the endometrium suggest an altered cellular state for pathological hyperplasia. Sphingolipids are bioactive compounds, and their biosynthesis and metabolism modulate a range of cellular processes including proliferation, migration and apoptosis. We demonstrate that aberrations in sphingolipid metabolism occur in women with endometriosis. METHODS Targeted mass spectrometry on >120 sphingolipids were… CONTINUE READING


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