Dysregulated peripheral and mucosal Th1/Th2 response in Whipple's disease.

  title={Dysregulated peripheral and mucosal Th1/Th2 response in Whipple's disease.},
  author={Thomas A Marth and Nicole Kleen and A Stallmach and Sabine Ring and Sheriff Aziz and Carsten L Schmidt and Warren Strober and Martin Zeitz and Thomas Schneider},
  volume={123 5},
BACKGROUND & AIMS An impaired monocyte function and impaired interferon (IFN)-gamma production has been suggested as a possible pathogenetic factor in Whipple's disease (WD) and as a cause for the delayed elimination of Tropheryma whipplei in some patients. METHODS We studied, in a series of 20 WD patients with various degrees of disease activity, cellular immune functions. RESULTS We found an increased in vitro production of interleukin (IL)-4 by peripheral mononuclear blood cells as… CONTINUE READING