Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis.

Abstract

Rheumatoid arthritis (RA) is a chronic, inflammatory disease of the synovium of uncertain pathogenesis. A number of phenotypic and functional T-cell defects have been described in RA, including abnormal clonal expansions and suppressed proliferative responses, which suggest a defect in T-cell differentiation. Here, we show that RA patients possess fewer… (More)

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Cite this paper

@article{Ponchel2002DysregulatedLP, title={Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis.}, author={Fr{\'e}d{\'e}rique Ponchel and Ann W Morgan and Sarah J. Bingham and Mark A. Quinn and Maya H. Buch and R obert J Verburg and J. A. Henwood and Susan H Douglas and Aur{\'e}lie Masurel and Philip G. Conaghan and Moji Gesinde and J. Andrew Taylor and Alexander F. Markham and P T J Emery and Jacob M van Laar and John Dudley Isaacs}, journal={Blood}, year={2002}, volume={100 13}, pages={4550-6} }