Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells.

@article{Carrabino2006DysregulatedIS,
  title={Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells.},
  author={Salvatore Carrabino and Daniela Carpani and Alessandra Livraghi and Maurizio Di Cicco and Diana Costantini and Elena Copreni and Carla Colombo and Massimo Conese},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2006},
  volume={5 2},
  pages={113-9}
}
BACKGROUND It is not clear whether cystic fibrosis (CF) airway inflammation is a consequence of bacterial infection or is intrinsically dysregulated. The aim of this study was to investigate IL-8 secretion and NF-kappaB activity in primary respiratory epithelial cells cultured from nasal polyps obtained from CF and non-CF subjects. METHODS NF-kappaB activity was studied by electrophoretic mobility-shift and quantitative colorimetric assays in nuclear extracts. Immunoreactive IL-8 levels were… CONTINUE READING

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