Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

@inproceedings{Chen2018DysregulatedHL,
  title={Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing},
  author={Shouwen Chen and Dahai Yang and Ying Wen and Zhiwei Jiang and Lingzhi Zhang and Jiatiao Jiang and Yaozhen Chen and Tianjian Hu and Qiyao Wang and Yuanxing Zhang and Qin Liu},
  booktitle={PLoS pathogens},
  year={2018}
}
Inflammatory caspase-11/4/5 recognize cytosolic LPS from invading Gram-negative bacteria and induce pyroptosis and cytokine release, forming rapid innate antibacterial defenses. Since extracellular or vacuole-constrained bacteria are thought to rarely access the cytoplasm, how their LPS are exposed to the cytosolic sensors is a critical event for pathogen recognition. Hemolysin is a pore-forming bacterial toxin, which was generally accepted to rupture cell membrane, leading to cell lysis… CONTINUE READING
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