Dysregulated expression of the IL-2 receptor beta-chain abrogates development of NK cells and Thy-1+ dendritic epidermal cells in transgenic mice.

@article{Suwa1995DysregulatedEO,
  title={Dysregulated expression of the IL-2 receptor beta-chain abrogates development of NK cells and Thy-1+ dendritic epidermal cells in transgenic mice.},
  author={Hiroshi Suwa and Toshiyuki Tanaka and Fujiko Kitamura and Tetsuo Shiohara and Keisuke Kuida and Masayuki Miyasaka},
  journal={International immunology},
  year={1995},
  volume={7 9},
  pages={1441-9}
}
The IL-2 receptor beta-chain (IL-2R beta), a specificity-determining subunit in the IL-2R complex with a restricted tissue distribution pattern, is essential for signal transduction. Our previous studies demonstrate that the continuous treatment of mice with anti-IL-2R beta resulted in the complete disappearance of NK cells and Thy-1+ dendritic epidermal cells (Thy-1+ dEC), suggesting that signals through IL-2R beta are critically involved in development of these lymphocyte subsets. However… CONTINUE READING