Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice.

@article{Mary2000DysregulatedEO,
  title={Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice.},
  author={C. Jinitha Mary and Catherine Laporte and Daniel Parzy and Mario L Santiago and Franck O. P. Stefani and Fr{\'e}d{\'e}ric Lajaunias and Robert Michael Evans Parkhouse and Theresa L. O'Keefe and Michael Neuberger and Shozo Izui and Luc Reininger},
  journal={Journal of immunology},
  year={2000},
  volume={165 6},
  pages={2987-96}
}
The Cd22 gene encodes a B cell-specific adhesion molecule that modulates B cell Ag receptor-mediated signal transduction, and is allelic to a lupus-susceptibility locus in New Zealand White (NZW) mice. In this study, we show that, in addition to the wild-type transcripts, NZW (Cd22a) mice synthesize aberrant CD22 mRNAs that contain approximately 20-120 nucleotide insertions upstream of the coding region between exons 2 and 3, and/or approximately 100-190 nucleotide deletions of exon 4. Sequence… CONTINUE READING

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