Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure.

@article{Ma2016DysregulatedET,
  title={Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure.},
  author={Mancheong Ma and Peng Li and Hua Shen and Kristine D Estrada and J Xu and Shubha R Kumar and Henry M Sucov},
  journal={Developmental biology},
  year={2016},
  volume={409 1},
  pages={272-276}
}
Heart outflow tract septation in mouse embryos carrying mutations in retinoic acid receptor genes fails with complete penetrance. In this mutant background, ectopic TGFβ signaling in the distal outflow tract is responsible for septation failure, but it was uncertain what tissue was responsive to ectopic TGFβ and why this response interfered with septation… CONTINUE READING