Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma

@inproceedings{CastilloGonzlez2015DysregulatedCN,
  title={Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma},
  author={Ana Cristina Castillo-Gonz{\'a}lez and Susana Nieto-Cer{\'o}n and Juan Pablo Pelegr{\'i}n-Hern{\'a}ndez and Mar{\'i}a Fernanda Montenegro and Jos{\'e} Antonio Noguera and Mar{\'i}a Fuensanta L{\'o}pez-Moreno and Jos{\'e} Neptuno Rodr{\'i}guez-L{\'o}pez and Cecilio J. Vidal and Diego Hell{\'i}n-Meseguer and Juan Cabezas-Herrera},
  booktitle={BMC Cancer},
  year={2015}
}
In airways, a proliferative effect is played directly by cholinergic agonists through nicotinic and muscarinic receptors activation. How tumors respond to aberrantly activated cholinergic signalling is a key question in smoking-related cancer. This research was addressed to explore a possible link of cholinergic signalling changes with cancer biology. Fifty-seven paired pieces of head and neck squamous cell carcinoma (HNSCC) and adjacent non-cancerous tissue (ANCT) were compared for their mRNA… CONTINUE READING