Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation.

@article{Paria2001DysregulatedCS,
  title={Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation.},
  author={Bibhash C. Paria and Huiping Song and Xiumei Wang and Patricia C. Schmid and Randy J. Krebsbach and Harald H. O. Schmid and Tom I. Bonner and Andreas Zimmer and Sudhansu K Dey},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 23},
  pages={20523-8}
}
The mechanisms by which synchronized embryonic development to the blastocyst stage, preparation of the uterus for the receptive state, and reciprocal embryo-uterine interactions for implantation are coordinated are still unclear. We show in this study that preimplantation embryo development became asynchronous in mice that are deficient in brain-type (CB1) and/or spleen-type (CB2) cannabinoid receptor genes. Furthermore, whereas the levels of uterine anandamide (endocannabinoid) and blastocyst… CONTINUE READING