Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer

@article{Huang2020DysregulatedFS,
  title={Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer},
  author={Po-Shuan Huang and Yang-Hsiang Lin and Hsiang-Cheng Chi and Y H Tseng and Cheng Chen and Tzu-Kang Lin and Chau-Ting Yeh and Kwang-Huei Lin},
  journal={Cells},
  year={2020},
  volume={9}
}
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies worldwide. Long non-coding (lnc) RNAs regulate complex cellular functions, such as cell growth, differentiation, metabolism, and metastasis. Although deregulation of lncRNA expression has been detected in HCC, many of the hepato-carcinogenesis-associated lncRNAs remain yet unidentified. Here, we aimed to investigate the involvement of a specific HCC-dysregulated lncRNA, FAM215A, and characterize its… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
Long noncoding RNA GAS5 inhibits metastasis by targeting miR-182/ANGPTL1 in hepatocellular carcinoma.
TLDR
This study first reveals the mechanism of GAS5/miR-182/ANGPTL1 axis in suppressing HCC metastasis, which provides promising new avenues for therapeutic intervention against HCC progression. Expand
Lamp2a is required for tumor growth and promotes tumor recurrence of hepatocellular carcinoma.
TLDR
Impaired Lamp2a expression in HCC contributes to tumor cell viability and promotes tumor growth and recurrence, and Targeting chaperone-mediated autophagy through Lamp 2a may also imply a potentially novel treatment strategy for HCC. Expand
Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression
TLDR
Findings collectively indicate that NEK2 modulates hepatoma cell functions, including growth, drug resistance, metastasis and angiogenesis via downstream genes activation, which is associated with poor overall survival in patients with HCC. Expand
miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2
TLDR
The findings of this study suggest that miR-103 promotes HCC metastasis and EMT by directly inhibiting LATS2, a key component of the Hippo signaling pathway, and may prove to be a promising therapeutic strategy for HCC. Expand
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer
TLDR
Data show that methylation-dependent tissue-specific regulation of the lncRNA MEG3 by miR-29a may contribute to HCC growth and highlight the inter-relationship between two classes of non-coding RNA, miRNAs and lncRNAs, and epigenetic regulation of gene expression. Expand
The cisplatin-induced lncRNA PANDAR dictates the chemoresistance of ovarian cancer via regulating SFRS2-mediated p53 phosphorylation
TLDR
PANDAR serves as a negative regulator of cisplatin sensitivity in human ovarian cancer via PANDAR-SRFS2-p53 feedback regulation in nuclear, and the role of PANDar in chemoresistance was confirmed in patients with ovarian cancer. Expand
Repression of lncRNA NEAT1 enhances the antitumor activity of CD8+T cells against hepatocellular carcinoma via regulating miR-155/Tim-3.
TLDR
By modulating the miR-155/Tim-3 pathway, repression of NEAT1 restrained CD8+T cell apoptosis and enhanced the cytolysis activity against HCC, implying an effective target for improving the outcome of immunotherapy. Expand
Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer.
TLDR
LncRNAs may play appreciable roles in ovarian cancer and more research is needed to elucidate their biological mechanisms and clinical implications in tumor characterization as well as disease prognosis and treatment. Expand
Taurine up‐regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma
TLDR
It is shown that knockdown of taurine up‐regulated gene 1 (TUG1) induces marked inhibition of cell migration, invasion, and glycolysis through suppression of microRNA (miR)‐455‐3p, and novel regulatory associations among TUG1, miR, AMPKβ2, and HK2 are an important determinant ofglycolytic metabolism and metastasis in HCC cells. Expand
Histone deacetylase 2 regulates the doxorubicin (Dox) resistance of hepatocarcinoma cells and transcription of ABCB1
TLDR
The results showed that the expression of HDAC2 was significantly increased in HCC doxorubicin (Dox) resistant cells as compared with their corresponding control cells. Expand
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