Dysphagia in Inclusion Body Myositis: Clinical Features, Management, and Clinical Outcome

@article{Oh2008DysphagiaII,
  title={Dysphagia in Inclusion Body Myositis: Clinical Features, Management, and Clinical Outcome},
  author={Terry H. Oh and Kathlyn A. Brumfield and Tanya L. Hoskin and Jan L. Kasperbauer and Jeffrey R. Basford},
  journal={American Journal of Physical Medicine \& Rehabilitation},
  year={2008},
  volume={87},
  pages={883-889}
}
Oh TH, Brumfield KA, Hoskin TL, Kasperbauer JL, Basford JR: Dysphagia in inclusion body myositis. Am J Phys Med Rehabil 2008;87:883–889. Objective:To evaluate the clinical features, treatment strategies, and outcome of dysphagia in patients with inclusion body myositis. Design:Retrospective review of all 26 patients (20 women, 6 men, mean age of 72.2 yrs) with inclusion body myositis-associated dysphagia seen in 1997–2001 at our institution. Results:Twenty-four patients (92%) had a dysphagia… 
Detecting dysphagia in inclusion body myositis
TLDR
Two questions reliably predict the presence of IP on VFS: ‘Does food get stuck in your throat’ and ‘Do you have to swallow repeatedly in order to get rid of food’ are an appropriate means in selecting IBM patients for further investigation through VFS and eventual treatment.
Myopathies featuring early or prominent dysphagia.
TLDR
Rapidly progressive dysphagia may predict immunotherapy responsiveness and IBM and IMNM accounted for approximately two-thirds of patients with early or prominent dysphAGia at the authors' institution.
Impact and Management of Dysphagia in Inflammatory Myopathies
TLDR
Evaluation of dysphagia in myositis requires thorough clinical workup and appropriate instrumental procedures, and controlled trials and consensus on best patient care are required for this important symptom.
Botulinum toxin treatment improves dysphagia in patients with oculopharyngeal muscular dystrophy and sporadic inclusion body myositis
TLDR
Botulinum toxin injection of the cricopharyngeal muscle in patients with OPMD and sIBM had a beneficial effect on dysphagia in most of the treated patients.
Dysphagia Due to Inclusion Body Myositis
TLDR
Inclusion body myositis is a chronic progressive acquired myopathy, uniquely distinguished by its selective muscle involvement, normal or moderately elevated muscle enzyme concentrations, and a progressive corticosteroid-resistant course.
Inclusion body myositis- A rare cause of dysphagia
TLDR
A case of 74 year old Caucasian lady, who has a background of inclusion body myositis and presented with a history of chronic dysphagia, who noticed sudden worsening of symptoms and was treated with balloon dilatation of cricopharyngeus inlet.
The Impact of Dysphagia in Myositis: A Systematic Review and Meta-Analysis
TLDR
Dysphagia should be included as a therapeutic target, especially in the outlined high-risk groups, according to a systematic review on epidemiology, pathophysiology, outcome and therapy and a meta-analysis on the prevalence of dysphagia in IIM.
Dysphagia in Patients with Sporadic Inclusion Body Myositis: Management Challenges
TLDR
Dysphagia in inclusion body myositis is common and associated with increased mortality and morbidity due to aspiration pneumonia, malnutrition and dehydration and increased knowledge of the aetiopathogenesis is likely to change the approach to treatment and improve the quality of life for patients.
...
...

References

SHOWING 1-10 OF 35 REFERENCES
Dysphagia in inflammatory myopathy: clinical characteristics, treatment strategies, and outcome in 62 patients.
TLDR
Dysphagia is a serious and at times presenting problem in patients with inflammatory myopathy and appears to be most refractory in Patients with IBM, with cricopharyngeal myotomy being most beneficial.
Management of dysphagia in inclusion body myositis.
TLDR
A patient is described in whom severe progressive dysphagia associated with inclusion body myositis developed and was successfully treated by cricopharyngeal myotomy.
Inclusion body myositis: analysis of 32 cases.
TLDR
While clinical improvement with therapy is rare, the observations support recent reports that therapy may be associated with a slower rate of clinical progression, and Optimal therapy remains uncertain, but the use of low dose methotrexate and prednisone may warrant further study.
Inclusion body myositis: analysis of 32 cases.
TLDR
While clinical improvement with therapy is rare, the observations support recent reports that therapy may be associated with a slower rate of clinical progression, and Optimal therapy remains uncertain, but the use of low dose methotrexate and prednisone may warrant further study.
Biomechanics, diagnosis, and treatment outcome in inflammatory myopathy presenting as oropharyngeal dysphagia
TLDR
The myopathic process is strongly associated with restricted sphincter opening suggesting that cricopharyngeal disruption is a useful adjunct to immunosuppressive therapy and the condition has a poor prognosis.
Inclusion body myositis. Clinical features and clinical course of the disease in 64 patients.
TLDR
IBM has a unique distribution of muscle weakness: ventral extremity muscle groups were more affected than dorsal muscle groups and girdle muscles were least affected, the latter preserving postural stability.
Inclusion body myositis. Observations in 40 patients.
TLDR
The findings support the notion that IBM is a distinct entity in which a set of pathological features is associated with a constellation of clinical findings, and Prednisone treatment at dose levels frequently effective in polymyositis failed to prevent disease progression in those patients observed for 2 or more years.
Inclusion body myositis: clinical, morphological, physiological and laboratory findings in 18 cases
TLDR
The results show that IBM may be associated with immunodeficiency, and that prednisone treatment may temporarily improve the clinical signs and provide basis for future studies on treatment of IBM.
Swallowing therapy in patients with neurological disorders causing cricopharyngeal dysfunction
TLDR
It is concluded that in neurological patients with CP, dysfunction can effectively be treated with swallowing therapy and that surgical approaches to CP dysfunction should be deferred pending the outcome of conservative management.
Dysphagia in inclusion body myositis.
TLDR
It is suggested that inclusion body myositis is not an infrequent cause of dysphagia in elderly people, and is amenable to treatment.
...
...