Dyspepsia: Organic Versus Functional

@article{Oustamanolakis2012DyspepsiaOV,
  title={Dyspepsia: Organic Versus Functional},
  author={Pantelis Oustamanolakis and Jan Tack},
  journal={Journal of Clinical Gastroenterology},
  year={2012},
  volume={46},
  pages={175–190}
}
Dyspepsia is the medical term for difficult digestion. It consists of various symptoms in the upper abdomen, such as fullness, discomfort, early satiation, bloating, heartburn, belching, nausea, vomiting, or pain. The prevalence of dyspepsia in the western world is approximately 20% to 25%. Dyspepsia can be divided into 2 main categories: “organic” and “functional dyspepsia” (FD). Organic causes of dyspepsia are peptic ulcer, gastroesophageal reflux disease, gastric or esophageal cancer… 

Functional dyspepsia

Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology:

MODERN APPROACH TO DYSPEPSIA

TLDR
Functional dyspepsia is a disorder characterized by dyspeptic symptoms which are located in the epigastrium and related to digestion of food in the initial part of the digestive system and its mechanisms need to be fully elucidated to enable finding appropriate therapy for all patient subgroups.

The Diagnosis and Treatment of Functional Dyspepsia.

TLDR
The impaired quality of life of patients with functional dyspepsia implies the need for definitive establishment of the diagnosis, followed by symptom-oriented treatment for the duration of the symptomatic interval.

Therapeutic Options for Functional Dyspepsia

Functional dyspepsia (FD) is defined by the presence of chronic gastroduodenal symptoms in the absence of organic or systemic disease that explains them, and a negative upper endoscopy. According to

Understanding the Biliary Dyspepsia

  • Hyun-So Kim
  • Medicine
    The Korean Journal of Pancreas and Biliary Tract
  • 2018
TLDR
Initial treatment of functional biliary disorder is adequate dietary control and medication, but if the symptoms worsened or recurred frequently, laparoscopic cholecystectomy could be performed with gallbladder dyskinesia.

The Role of Diet in Counteracting Gastroparesis

TLDR
The general principles for treating symptomatic gastroparesis are to reduce symptoms, correct and prevent fluid, electrolyte and nutritional deficiencies, and identify and treat the concomitant comorbidities.

Functional gastroduodenal disorders

TLDR
Mechanisms of functional nausea and vomiting are poorly understood, and their treatment currently focuses on pharmacological and non-pharmacological therapies, including antidepressants and psychological approaches.

Functional Dyspepsia: An Enigma in a Conundrum

ABSTRACT As defined by Rome III, there are 4 abdominal pain-related functional gastrointestinal disorders in children: irritable bowel syndrome, functional dyspepsia (FD), abdominal migraine, and

Serological assessment of samples from patients complaining of dyspepsia

TLDR
Using the results from the serological analysis of the patients’ serum the clinician can delineate between gastric atrophy and a normal health stomach usually without the need to refer the patient for endoscopy.

Psychological Distress in Dyspepsia Markku Pajala Psychological Distress in Dyspepsia

TLDR
It seems, that mental distress and suspicion of serious illness is merely a nonspecific reaction to abdominal symptoms, which does not support the idea of brain-gut axis in functional dyspepsia, and questions the proposed specific link between gut and brain.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Impact of Coexisting Irritable Bowel Syndrome on Symptoms and Pathophysiological Mechanisms in Functional Dyspepsia

TLDR
Functional dyspepsia + IBS is more prevalent in female patients and is associated with a higher weight loss, with greater overall symptom severity, and with hypersensitivity to distention.
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