Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice.

@article{Pitera2004DysmorphogenesisOK,
  title={Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice.},
  author={Jolanta E. Pitera and Adrian S Woolf and Nicholas Gale and George D. Yancopoulos and Hai-tao Yuan},
  journal={The American journal of pathology},
  year={2004},
  volume={165 6},
  pages={1895-906}
}
Angiopoietin-2 (Ang-2) modulates Tie-2 receptor activation. In mouse kidney maturation, Ang-2 is expressed in arteries, with lower levels in tubules, whereas Tie-2 is expressed by endothelia. We hypothesized that Ang-2 deficiency disrupts kidney vessel patterning. The normal renal cortical peritubular space contains fenestrated capillaries, which have few pericytes; they receive water and solutes which proximal tubules reclaim from the glomerular filtrate. In wild-type neonates, alpha smooth… CONTINUE READING

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