Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase.

@article{Savransky2008DyslipidemiaAA,
  title={Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase.},
  author={Vladimir Savransky and Jonathan C Jun and Jianguo Li and Ashika Nanayakkara and Shannon Fonti and Ann Moser and Kimberly E Steele and Michael A. Schweitzer and Susheel P. Patil and Sanjay Bhanot and Alan R. Schwartz and Vsevolod Y Polotsky},
  journal={Circulation research},
  year={2008},
  volume={103 10},
  pages={1173-80}
}
Obstructive sleep apnea leads to chronic intermittent hypoxia (CIH) and is associated with atherosclerosis. We have previously shown that C57BL/6J mice exposed to CIH and a high-cholesterol diet develop dyslipidemia, atherosclerosis of the aorta, and upregulation of a hepatic enzyme of lipoprotein secretion, stearoyl coenzyme A desaturase 1 (SCD-1). We hypothesized that (1) SCD-1 deficiency will prevent dyslipidemia and atherosclerosis during CIH; and (2) human OSA is associated with… CONTINUE READING

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