Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death.

@article{Suna2009DysideamineAN,
  title={Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death.},
  author={Hideaki Suna and Masayoshi Arai and Yoshie Tsubotani and Asami Hayashi and Andi Setiawan and Motomasa Kobayashi},
  journal={Bioorganic \& medicinal chemistry},
  year={2009},
  volume={17 11},
  pages={
          3968-72
        }
}
Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury
TLDR
It is found that EDA attenuated IAA-induced cell injury in CGNs and significantly reduced intracellular reactive oxidative stress production, loss of mitochondrial membrane potential, and caspase 3 activity induced by IAA.
A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine
TLDR
T-006 significantly ameliorated memory impairments in APP/PS1 transgenic mice and multiple functions of a single molecule suggest that T-006 is a promising novel neuroprotective agent for treating various neurodegenerative disorders, including and in particular Alzheimer's disease.
Dysidaminones A–M, cytotoxic and NF-κB inhibitory sesquiterpene aminoquinones from the South China Sea sponge Dysidea fragilis
TLDR
Preliminary structure–activity relationship analysis indicated that 18-aminosubstituted sesquiterpene quinones with exocyclic double bond (Δ4,11) are cytotoxic agents and NF-κB inhibitors.
Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
TLDR
This review will focus on the most promising marine drugs’ neuroprotective potential for neurodegenerative disorders, such as Parkinson’s and Alzheimer's diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties.
Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases
TLDR
Their role in neuroscience research and development of new therapies targeting the central nervous system will be addressed, with particular focus on neuroinflammation and neurodegeneration.
Bioactive sesquiterpene quinols and quinones from the marine sponge Dysidea avara
Four new sesquiterpene quinols, dysiquinols A–D (1–4), and four new sesquiterpene quinones, (5S,8S,9R,10S)-18-ethoxyneoavarone (5), (5S,8S,9R,10S)-19-ethoxyneoavarone (6),
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References

SHOWING 1-10 OF 30 REFERENCES
Crambescidin 800, a pentacyclic guanidine alkaloid, protects a mouse hippocampal cell line against glutamate-induced oxidative stress
TLDR
Crambescidin 800 showed no effect on the depletion of intracellular glutathione of HT22 cells induced by glutamate, and production of reactive oxygen species (ROS) and activation of mitogen-activated protein kinase (MAPK) were inhibited only by the high concentration of 1.06 μM (EC50) concentration.
VIP-related protection against lodoacetate toxicity in pheochromocytoma (PC12) cells
TLDR
A short exposure to SNV provided potent protection from iodoacetate-induced toxicity suggesting that SNV may have therapeutic value in the treatment of ischemic/hypoxic injury.
Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells
TLDR
Results indicate that transcriptional inducers, such as Forskolin, can sufficiently up-regulate cellular AChE production and protect cells against organophosphate toxicity.
A Novel Neurotrophic Agent, T-817MA [1-{3-[2-(1-Benzothiophen-5-yl) Ethoxy] Propyl}-3-azetidinol Maleate], Attenuates Amyloid-β-Induced Neurotoxicity and Promotes Neurite Outgrowth in Rat Cultured Central Nervous System Neurons
TLDR
It is suggested that T-817MA exerts neuroprotective effect and promotes neurite outgrowth in rat primary cultured neurons and may have a potential for disease modification and be useful for patients with neurodegenerative diseases, such as AD.
Effect of a Novel Free Radical Scavenger, Edaravone (MCI-186), on Acute Brain Infarction
TLDR
Edaravone represents a neuroprotective agent which is potentially useful for treating acute ischemic stroke, since it can exert significant effects on functional outcome as compared with placebo.
Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives.
TLDR
3,9-bis[(ethylthio)methyl]-K-252a (8) was identified as a potent and selective neurotrophic agent in vitro as measured by enhancement of choline acetyltransferase activity in embryonic rat spinal cord and basal forebrain cultures.
Oxidative stress, glutamate, and neurodegenerative disorders.
TLDR
Two broad mechanisms--oxidative stress and excessive activation of glutamate receptors--are converging and represent sequential as well as interacting processes that provide a final common pathway for cell vulnerability in the brain.
...
...