Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease.

@article{Kudo2011DysfunctionsIC,
  title={Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease.},
  author={Takashi Kudo and Analyne M. Schroeder and Dawn H Loh and Dika Kuljis and Maria Veronica Clavijo Jordan and Kenneth P. Roos and Christopher S Colwell},
  journal={Experimental neurology},
  year={2011},
  volume={228 1},
  pages={80-90}
}
Many patients with Huntington's disease (HD) exhibit disturbances in their daily cycle of sleep and wake as part of their symptoms. These patients have difficulty sleeping at night and staying awake during the day, which has a profound impact on the quality of life of the patients and their care-givers. In the present study, we examined diurnal and circadian rhythms of four models of HD including the BACHD, CAG 140 knock-in and R6/2 CAG 140 and R6/2 CAG 250 lines of mice. The BACHD and both R6… CONTINUE READING

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