Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model.

@article{Pu2009DysfunctionalTG,
  title={Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model.},
  author={H. J. Pu and Joanne Collazo and Elisabeth Jones and Dustin T Gayheart and Shinichi Sakamoto and Adam Vogt and Bonnie Mitchell and Natasha Kyprianou},
  journal={Cancer research},
  year={2009},
  volume={69 18},
  pages={7366-74}
}
The contribution of a dysfunctional transforming growth factor-beta type II receptor (TGF beta RII) to prostate cancer initiation and progression was investigated in an in vivo mouse model. Transgenic mice harboring the dominant-negative mutant TGF-beta type II receptor (DNTGF beta RII) in mouse epithelial cell were crossed with the TRAMP prostate cancer transgenic mouse to characterize the in vivo consequences of inactivated TGF-beta signaling on prostate tumor initiation and progression… CONTINUE READING

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