Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model.

@article{Pu2009DysfunctionalTG,
  title={Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model.},
  author={H. Pu and Joanne Collazo and E. Jones and Dustin Gayheart and Shinichi Sakamoto and A. Vogt and Bonnie Mitchell and N. Kyprianou},
  journal={Cancer research},
  year={2009},
  volume={69 18},
  pages={
          7366-74
        }
}
  • H. Pu, Joanne Collazo, +5 authors N. Kyprianou
  • Published 2009
  • Biology, Medicine
  • Cancer research
  • The contribution of a dysfunctional transforming growth factor-beta type II receptor (TGF beta RII) to prostate cancer initiation and progression was investigated in an in vivo mouse model. Transgenic mice harboring the dominant-negative mutant TGF-beta type II receptor (DNTGF beta RII) in mouse epithelial cell were crossed with the TRAMP prostate cancer transgenic mouse to characterize the in vivo consequences of inactivated TGF-beta signaling on prostate tumor initiation and progression… CONTINUE READING
    Transforming Growth Factor-Beta in Prostate Cancer

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