Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene

@inproceedings{Hall2013DysfunctionalOP,
  title={Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene},
  author={Arnaldur Hall and Kathrine Damm Meyle and Marina Krarup Lange and Martin Kl{\'i}ma and May Sanderhoff and Christina Dahl and Cecilie Abildgaard and Katrine Almind Vinberg Thorup and Seyed Moein Moghimi and Per Bo Jensen and Jiri Bartek and Per Guldberg and C. Christensen},
  booktitle={Oncotarget},
  year={2013}
}
Oncogene addiction describes how cancer cells exhibit dependence on single oncogenes to escape apoptosis and senescence. While oncogene addiction constitutes the basis for new cancer treatment strategies targeting individual kinases and pathways activated by oncogenic mutations, the biochemical basis for this addiction is largely unknown. Here we provide evidence for a metabolic rationale behind the addiction to (V600E)BRAF in two malignant melanoma cell lines. Both cell lines display a… CONTINUE READING
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