Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells.

@article{Roth2004DysfunctionalIO,
  title={Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells.},
  author={Michael Roth and Peter A. Johnson and Peter Borger and Michel P. Bihl and Jochen R{\"u}diger and Gregory G. King and Qi Mu Ge and Katrin E. Hostettler and Janette K Burgess and J. L. Black and Michael Tamm},
  journal={The New England journal of medicine},
  year={2004},
  volume={351 6},
  pages={
          560-74
        }
}
BACKGROUND Increased proliferation of bronchial smooth-muscle cells may lead to increased muscle mass in the airways of patients with asthma. The antiproliferative effect of glucocorticoids in bronchial smooth-muscle cells in subjects without asthma is mediated by a complex of the glucocorticoid receptor and the CCAAT/enhancer binding protein alpha (C/EBPalpha). We examined the signaling pathway controlling the inhibitory effect of glucocorticoids on cell proliferation and interleukin-6… CONTINUE READING

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