Dysfunctional immunoregulation in human liver allograft rejection associated with compromised galectin-1/CD7 pathway function

@inproceedings{Wei2017DysfunctionalII,
  title={Dysfunctional immunoregulation in human liver allograft rejection associated with compromised galectin-1/CD7 pathway function},
  author={Sidong Wei and D. C. Cao and Zuojin Liu and Jinheng Li and Hank Wu and Jianping Gong and Yiming Liu and Yakun Wu},
  booktitle={Cell Death & Disease},
  year={2017}
}
Regulatory T cells in rejected allograft patients display an inability to control responder T cells. Galectin-1 (Gal1) inhibits responder T cells through binding CD7. We investigated whether the dysfunctional immunoregulation in liver allograft rejection patients results from reduced regulatory T-cell Gal1 expression and/or responder T-cell CD7 expression. Circulating regulatory T cells and responder T cells were profiled from 31 acute rejection transplant patients, 85 transplant patients in… CONTINUE READING
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