Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression

@article{GmezGaln2013DysfunctionalAR,
  title={Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression},
  author={Marta G{\'o}mez-Gal{\'a}n and Dimitri De Bundel and Ann Van Eeckhaut and Ilse J. Smolders and Maria Lindskog},
  journal={Molecular Psychiatry},
  year={2013},
  volume={18},
  pages={582-594}
}
Depression is usually associated with alterations in the monoaminergic system. However, new evidences suggest the involvement of the glutamatergic system in the aetiology of depression. Here we explored the glutamatergic system in a rat model of depression (i.e., the flinders sensitive line (FSL)) to reveal the mechanism underlying the emotional and cognitive aspects associated with the disease. We showed a dramatically elevated level of baseline glutamatergic synaptic transmission by whole… CONTINUE READING
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