Dysfunctional HCN ion channels in neurological diseases

@inproceedings{DiFrancesco2015DysfunctionalHI,
  title={Dysfunctional HCN ion channels in neurological diseases},
  author={Jacopo C DiFrancesco and Dario DiFrancesco},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems. HCN channels are activated by membrane hyperpolarization at voltages close to resting membrane potentials and carry the hyperpolarization-activated current, dubbed If (funny current) in heart and Ih in neurons. HCN channels contribute in several ways to neuronal activity and are responsible for many important… CONTINUE READING
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