Dysfunction of the ubiquitin–proteasome system in multiple disease conditions: therapeutic approaches

@article{Paul2008DysfunctionOT,
  title={Dysfunction of the ubiquitin–proteasome system in multiple disease conditions: therapeutic approaches},
  author={Subhankar Paul},
  journal={BioEssays},
  year={2008},
  volume={30}
}
  • S. Paul
  • Published 1 November 2008
  • Biology, Medicine
  • BioEssays
The ubiquitin–proteasome system (UPS) is the major proteolytic pathway that degrades intracellular proteins in a regulated manner. Deregulation of the UPS has been implicated in the pathogenesis of many neurodegenerative disorders like Alzheimer's disease, Parkinson's diseases, Huntington disease, Prion‐like lethal disorders, in the pathogenesis of several genetic diseases including cystic fibrosis, Angelman's syndrome and Liddle syndrome and in many cancers. Multiple lines of evidence have… Expand
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