Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity

@inproceedings{Nomoto2012DysfunctionOT,
  title={Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity},
  author={Masanori Nomoto and Yohei Takeda and Shusaku Uchida and Koji Mitsuda and Hatsune Enomoto and Kaori Saito and Tesu Choi and Ayako Miyamori Watabe and Shizuka Kobayashi and Shoichi Masushige and Toshiya Manabe and Satoshi Kida},
  booktitle={Molecular Brain},
  year={2012}
}
Retinoid signaling pathways mediated by retinoic acid receptor (RAR)/retinoid × receptor (RXR)-mediated transcription play critical roles in hippocampal synaptic plasticity. Furthermore, recent studies have shown that treatment with retinoic acid alleviates age-related deficits in hippocampal long-term potentiation (LTP) and memory performance and, furthermore, memory deficits in a transgenic mouse model of Alzheimer's disease. However, the roles of the RAR/RXR signaling pathway in learning and… CONTINUE READING
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