Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression.

@article{Scheubel2002DysfunctionOM,
  title={Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression.},
  author={Robert J. Scheubel and Mike Tostlebe and Andreas Simm and S. Owens Rohrbach and Roland Prondzinsky and Frank Norbert Gellerich and Rolf Edgar Silber and J{\"u}rgen Holtz},
  journal={Journal of the American College of Cardiology},
  year={2002},
  volume={40 12},
  pages={
          2174-81
        }
}
OBJECTIVES Activity of mitochondrial respiratory chain complexes with and without mitochondrially encoded subunits was assessed in failing human myocardium together with parameters of mitochondrial gene expression. BACKGROUND Mutations and deletions in mitochondrial genome (mtDNA) sporadically accumulate in the aging myocardium. In experimental heart failure, they are discussed to be a generalized problem resulting in disturbances of mitochondrial gene expression and mitochondrial function… CONTINUE READING
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