Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

@article{Kelley2002DysfunctionOM,
  title={Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.},
  author={David E Kelley and Jing Jing He and Elizabeth V. Menshikova and Vladimir B. Ritov},
  journal={Diabetes},
  year={2002},
  volume={51 10},
  pages={2944-50}
}
Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production. Because the insulin resistance of skeletal muscle in type 2 diabetes and obesity entails dysregulation of the oxidation of both carbohydrate and lipid fuels, the current study was undertaken to examine the potential contribution of perturbation of mitochondrial function. Vastus lateralis muscle was obtained by percutaneous biopsy during fasting conditions from lean (n = 10) and obese (n = 10) nondiabetic… CONTINUE READING
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