Dysfunction of hippocampal interneurons in epilepsy

@article{Liu2014DysfunctionOH,
  title={Dysfunction of hippocampal interneurons in epilepsy},
  author={Yu-Qiang Liu and Fang Yu and Wan-hong Liu and Xiao-hua He and Bi-Wen Peng},
  journal={Neuroscience Bulletin},
  year={2014},
  volume={30},
  pages={985-998}
}
Gamma-amino-butyric acid (GABA)-containing interneurons are crucial to both development and function of the brain. Down-regulation of GABAergic inhibition may result in the generation of epileptiform activity. Loss, axonal sprouting, and dysfunction of interneurons are regarded as mechanisms involved in epileptogenesis. Recent evidence suggests that network connectivity and the properties of interneurons are responsible for excitatory-inhibitory neuronal circuits. The balance between excitation… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 92 REFERENCES

Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Interneurons of the hippocampus

TF Fr eund, G. Buzsaki
  • Hippocampus 1996,
  • 1996
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL