Corpus ID: 91365380

Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis

  title={Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis},
  author={SeinosukeKawashima and MitsuhiroYokoyama},
Atherosclerosis is associated with an impairment of endothelium-dependent relaxations, which represents the reduced bioavailability of nitric oxide (NO) produced from endothelial NO synthase (eNOS). Among various mechanisms implicated in the impaired EDR in atherosclerosis, superoxide generated from dysfunctional eNOS has attracted attention. Under conditions in which vascular tissue levels of tetrahydrobiopterin (BH4), a cofactor for NOS, are deficient or lacking, eNOS becomes dysfunctional… Expand
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