Dysfunction of Collagen Synthesis and Secretion in Chondrocytes Induced by Wisp3 Mutation

@inproceedings{Wang2013DysfunctionOC,
  title={Dysfunction of Collagen Synthesis and Secretion in Chondrocytes Induced by Wisp3 Mutation},
  author={Min Wang and Xiao-Fei Man and Ya-Qing Liu and Er-yuan Liao and Zhi-Feng Shen and Xiang-Hang Luo and Li-juan Guo and Xian-ping Wu and Hou-de Zhou},
  booktitle={International journal of endocrinology},
  year={2013}
}
Wisp3 gene mutation was shown to cause spondyloepiphyseal dysplasia tarda with progressive arthropathy (SRDT-PA), but the underlying mechanism is not clear. To clarify this mechanism, we constructed the wild and mutated Wisp3 expression vectors and transfected into human chondrocytes lines C-20/A4; Wisp3 proteins subcellular localization, cell proliferation, cell apoptosis, and Wisp3-mediated gene expression were determined, and dynamic secretion of collagen in transfected chondrocytes was… CONTINUE READING
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