Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.

  title={Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.},
  author={Sakima A. Smith and Amy Curry Sturm and Jerry W Curran and Crystal F. Kline and Sean C. Little and Ingrid M. Bonilla and Victor P. Long and Michael A. Makara and Iuliia Polina and Langston D Hughes and Tyler R Webb and Zhiyi Wei and Patrick J Wright and Niels Voigt and Deepak Bhakta and Katherine G. Spoonamore and C Eleana Zhang and Raul Weiss and Philip F. Binkley and Paul M L Janssen and Ahmet Kilic and Robert Samuel DeCosta Higgins and Mingzhai Sun and Jianjie Ma and Dobromir Dobrev and Mingjie Zhang and Cynthia A. Carnes and Matteo Vatta and Matthew N Rasband and Thomas J. Hund and Peter J. Mohler},
  volume={131 8},
BACKGROUND The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal elements are tightly linked to cardiac pathologies, including myopathies, aortopathies, and dystrophies. Conversely, the link between cytoskeletal protein dysfunction and cardiac electric… CONTINUE READING



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