Dysferlin Mediates the Cytoprotective Effects of TRAF2 Following Myocardial Ischemia Reperfusion Injury

@inproceedings{Tzeng2014DysferlinMT,
  title={Dysferlin Mediates the Cytoprotective Effects of TRAF2 Following Myocardial Ischemia Reperfusion Injury},
  author={Huei‐Ping Tzeng and Sarah A. Evans and Feng Gao and Kari T. Chambers and Veli Kemal Topkara and Natarajan Sivasubramanian and P E Marilyn Barger and Douglas L. Mann},
  booktitle={Journal of the American Heart Association},
  year={2014}
}
BACKGROUND We have demonstrated that tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2), a scaffolding protein common to TNF receptors 1 and 2, confers cytoprotection in the heart. However, the mechanisms for the cytoprotective effects of TRAF2 are not known. METHODS/RESULTS Mice with cardiac-restricted overexpression of low levels of TRAF2 (MHC-TRAF2LC) and a dominant negative TRAF2 (MHC-TRAF2DN) were subjected to ischemia (30-minute) reperfusion (60-minute) injury (I/R), using… CONTINUE READING

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