[Dyserythropoietic anemia, type I: ineffective erythropoiesis due to disorders in the DNA-nucleoprotein complex].

Abstract

The relative DNA, RNA histone and hemoglobin contents and 3H-thymidine incorporation in vitro were determined sequentially in individual erythroblasts of type I dyserythropoietic anemia. The histone/DNA ratio was increased due to a rise in histone extinction, indicating a pathological DNA-nucleoprotein complex. In addition, the erythroblasts displayed an increase in DNA content exceeding tetraploid values, a loss of DNA-synthesis activity at immature stages with low hemoglobin content, and a reduction of RNA. These variations were assumed to be caused by the preceding and primary impairment of the DNA-nucleoprotein complex.

Cite this paper

@article{Meuret1975DyserythropoieticAT, title={[Dyserythropoietic anemia, type I: ineffective erythropoiesis due to disorders in the DNA-nucleoprotein complex].}, author={Gerhard Meuret and P Tschan}, journal={Schweizerische medizinische Wochenschrift}, year={1975}, volume={105 47}, pages={1580-1} }