Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

@article{Piters2016DysbiosisOU,
  title={Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients},
  author={Wouter A.A. de Steenhuijsen Piters and Elisabeth G. W. Huijskens and Anne L Wyllie and G. Robbert Biesbroek and Menno R van den Bergh and Reinier H. Veenhoven and Xinhui Wang and Krzysztof Trzciński and Marc Bonten and John W A Rossen and Elisabeth A. M. Sanders and Debby Bogaert},
  journal={The ISME Journal},
  year={2016},
  volume={10},
  pages={97-108}
}
Bacterial pneumonia is a major cause of morbidity and mortality in elderly. We hypothesize that dysbiosis between regular residents of the upper respiratory tract (URT) microbiome, that is balance between commensals and potential pathogens, is involved in pathogen overgrowth and consequently disease. We compared oropharyngeal microbiota of elderly pneumonia patients (n=100) with healthy elderly (n=91) by 16S-rRNA-based sequencing and verified our findings in young adult pneumonia patients (n=27… CONTINUE READING
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