Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

  title={Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure},
  author={Takehiro Kamo and Hiroshi Akazawa and Wataru Suda and Akiko Saga-Kamo and Yu Shimizu and Hiroki Yagi and Qing Liu and Seitaro Nomura and Atsuhiko Thomas Naito and Norifumi Takeda and Mutsuo Harada and Haruhiro Toko and Hidetoshi Kumagai and Yuichi Ikeda and Eiki Takimoto and Jun-Ichi Suzuki and Kenya Honda and Hidetoshi Morita and Masahira Hattori and Issei Komuro},
  booktitle={PloS one},
Emerging evidence has suggested a potential impact of gut microbiota on the pathophysiology of heart failure (HF). However, it is still unknown whether HF is associated with dysbiosis in gut microbiota. We investigated the composition of gut microbiota in patients with HF to elucidate whether gut microbial dysbiosis is associated with HF. We performed 16S ribosomal RNA gene sequencing of fecal samples obtained from 12 HF patients and 12 age-matched healthy control (HC) subjects, and analyzed… CONTINUE READING
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