Dysbiosis Anticipating Necrotizing Enterocolitis in Very Premature Infants

  title={Dysbiosis Anticipating Necrotizing Enterocolitis in Very Premature Infants},
  author={Kathleen Sim and Alexander George Shaw and Paul A Randell and Michael J. Cox and Zo{\"e} E. McClure and Ming-shi Li and Munther Haddad and Paul R Langford and William O C M Cookson and Miriam F Moffatt and J. Simon Kroll},
  booktitle={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
BACKGROUND Necrotizing enterocolitis (NEC) is a devastating inflammatory bowel disease of premature infants speculatively associated with infection. Suspected NEC can be indistinguishable from sepsis, and in established cases an infant may die within hours of diagnosis. Present treatment is supportive. A means of presymptomatic diagnosis is urgently needed. We aimed to identify microbial signatures in the gastrointestinal microbiota preceding NEC diagnosis in premature infants. METHODS Fecal… CONTINUE READING
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  • NIH Human Microbiom
  • HMP_MDG_454DEFAULTPROTOCOL.V4.2. Available at…
  • 2014
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