Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways

@article{Papaleo2012Dysbindin1MP,
  title={Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways},
  author={Francesco Papaleo and Feng Yang and Susana Navarro Garc{\'i}a and J Chen and Bin Lu and Jacqueline N. Crawley and Daniel R. Weinberger},
  journal={Molecular Psychiatry},
  year={2012},
  volume={17},
  pages={85-98}
}
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys−/−) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related… CONTINUE READING
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Dysbindin-1 and its protein family

  • K Talbot, WY Ong, DJ Blake, J Tang, N Louneva, GC Carlson
  • Javitt D, Kantorowitz J (eds). Handbook of…
  • 2009

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