Dysbalance of neuronal second messenger function in the aetiology of affective disorders: A pathophysiological concept hypothesising defects beyond first messenger receptors

@article{Wachtel1989DysbalanceON,
  title={Dysbalance of neuronal second messenger function in the aetiology of affective disorders: A pathophysiological concept hypothesising defects beyond first messenger receptors},
  author={Helmut Wachtel},
  journal={Journal of Neural Transmission},
  year={1989},
  volume={75},
  pages={21-29}
}
It is suggested that affective disorders arise from the dysbalance of the two major intraneuronal signal amplification systems, the adenylate cyclase and the phospholipase C system, with depression resulting from underfunction of cyclic adenosine 3′,5′-monophosphate-mediated effector cell responses associated with an absolute or relative dominance of the inositoltriphosphate/ diacylglycerol-mediated responses and mania resulting from the converse. The usefulness of this hypothesis is discussed… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Mode of action of lithium on the catalytic unit of adenylate cyclase from rat brain

  • A Mork, A Geisler
  • Pharmacol Toxicol
  • 1987
1 Excerpt

Effects of forskolin and cyclic nucleotides in animal model predictive of antidepressant activity: Interactions with rolipram

  • H Wachtel
  • Willner P
  • 1986

Similar Papers

Loading similar papers…