Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells.

@article{Yabut2010Dyrk1AOI,
  title={Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells.},
  author={Odessa R. Yabut and Jason D Domogauer and G V D'arcangelo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 11},
  pages={4004-14}
}
Dyrk1A is a member of the mammalian Dyrk [dual-specificity tyrosine-(Y)-phosphorylation regulated kinase] family of protein kinases that is expressed at high levels in the brain, but its role in the development and function of this organ is not well understood. The human DYRK1A gene is located on trisomic chromosome 21 in Down syndrome (DS) patients, leading to its overexpression. Dyrk1A is also overexpressed in animal models of DS and in gene-specific transgenic mice that consistently exhibit… CONTINUE READING
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