Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates.

Abstract

The mechanisms underlying aggregate formation in age-related neurodegenerative diseases remain not well understood. Here we investigated whether dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (Dyrk1A) is involved in the formation of regulator of calcineurin 1 (RCAN1) aggregates. We show that RCAN1 self-associates and forms multimers, and… (More)
DOI: 10.1016/j.neulet.2013.08.066

Cite this paper

@article{Song2013Dyrk1AmediatedPO, title={Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates.}, author={Woo-Joo Song and Eun-Ah Christine Song and Sun Hee Choi and Hyung-Hwan Baik and Byung Kwan Jin and Jeong Hee Kim and Sul-Hee Chung}, journal={Neuroscience letters}, year={2013}, volume={554}, pages={135-40} }