Dynorphins in regulation of immune system functions

Abstract

Dynorphins constitute a family of opioid peptides manifesting the highest affinity for κ-opiate receptors. Immune system cells are known to express a κ-receptor similar to that in the central nervous system, and as a consequence dynorphins are involved in the interaction between cells of the nervous and immune systems. In this review, data on dynorphin structure are analyzed and generalized, the κ-opiate receptor is characterized, and data on the regulation by dynorphins of functioning of the innate and adaptive immunity cells are summarized.

DOI: 10.1134/S0006297914050034

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@article{Gein2014DynorphinsIR, title={Dynorphins in regulation of immune system functions}, author={Sergey V Gein}, journal={Biochemistry (Moscow)}, year={2014}, volume={79}, pages={397-405} }