Dynorphin opioid inhibition of cocaine‐induced, D1 dopamine receptor‐mediated immediatem‐early gene expression in the striatum

@article{Steiner1995DynorphinOI,
  title={Dynorphin opioid inhibition of cocaine‐induced, D1 dopamine receptor‐mediated immediatem‐early gene expression in the striatum},
  author={Heinz Steiner and Charles R. Gerfen},
  journal={Journal of Comparative Neurology},
  year={1995},
  volume={353}
}
Neurons in the striatum that project to the substantia nigra contain the opioid peptide dynorphin. Stimulation of D1 dopamine receptors results in increased expression of mRNA encoding dynorphin as well as expression of immediate‐early genes such as c‐fos in these neurons. Levels of dynorphin vary in different regions of the normal rat striatum, being highest in ventral and medial striatum. In a prior study, we have shown that both regional and temporal patterns of c‐fos induction following… Expand
Enkephalin regulates acute D2 dopamine receptor antagonist-induced immediate-early gene expression in striatal neurons
TLDR
The present findings suggest that opioid peptides in the striatum serve as negative feedback systems to regulate the striatal output pathways in which they are expressed, and enkephalin acts, via mu and delta receptors in the Striatum, to inhibit acute effects of D2 receptor blockade in striatopallidal neurons. Expand
Dynorphin regulates D1 dopamine receptor‐mediated responses in the striatum: Relative contributions of pre‐ and postsynaptic mechanisms in dorsal and ventral striatum demonstrated by altered immediate‐early gene induction
TLDR
The results indicate that dynorphin in the striatum functions to regulate dopamine input to striatonigral neurons, acting at both pre‐ and postsynaptic sites, and that the relative contributions of these mechanisms differ between dorsal and ventral striatal regions. Expand
D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum
TLDR
The results demonstrate that some of the effects of cocaine on gene regulation are mediated via D1 receptor-dependent mechanisms, as evidenced by the absence of immediate-early gene induction in D1-deficient mice, whereas others also involve additional, non-D1 receptor mechanisms,As shown for substance P expression. Expand
Dopamine-mediated gene regulation in the striatum.
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Functional data support the view that D1 and D2 dopamine receptors are segregated, respectively, to direct and indirect striatal output pathways. Expand
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TLDR
The results indicate that striatal D1 receptors are critical for gene induction by methylphenidate, and suggest that D1 receptor-stimulated striatal output exerts robust control over widespread striatal activities/gene expression via regulation of input to the striatum. Expand
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TLDR
The results suggest that the specific function of dynorphin and enkephalin is to dampen excessive activation of these neurons by dopamine and other neurotransmitters. Expand
Activation of metabotropic glutamate receptor mediates upregulation of transcription factor mRNA expression in rat striatum induced by acute administration of amphetamine
TLDR
Data indicate that blockade of total mGluRs in the dorsal striatum has a selective effect on dopamine-stimulated gene expression, which is required for the upregulation of transcription factor c-fos, although not zif/268, mRNA expression in the striatum in response to acute injection of amphetamine. Expand
Amphetamine and cocaine induce different patterns of c‐fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context
TLDR
The neural circuitry engaged by psychostimulant drugs, and their ability to induce specific patterns of gene expression, are determined by the environmental context in which they are experienced, and may be related to the ability of environmental novelty to facilitate psychostIMulant drug‐induced neuroplasticity. Expand
D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons
  • C. Gerfen, K. Keefe, E. Gauda
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Data indicate that the synergistic response to combined D1- and D2-receptor stimulation is mediated by interneuronal interactions involving the activation of D1 and D1 receptors on separate populations of striatal neurons. Expand
Regulation of Rat Cortex Function by D1 Dopamine Receptors in the Striatum
TLDR
stimulation of D1 dopamine receptors in the striatum exerts a widespread facilitatory effect on cortical function, suggesting that changes in cortical gene expression could reflect altered cortical function. Expand
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