Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity.

@article{McGinty1983DynorphinIC,
  title={Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity.},
  author={Jacqueline F McGinty and Steven J. Henriksen and Avram Goldstein and Lars Terenius and Floyd E. Bloom},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 2},
  pages={589-93}
}
Antisera raised against synthetic dynorphin or [Leu5]enkephalin demonstrate immunostaining in hippocampal mossy fibers and in dentate granule cells. However, dynorphin immunoreactivity (ir) appears to be denser in immunocytochemical preparations and is quantitatively greater by radioimmunoassay than enkephalin-ir. Immunostaining with dynorphin antisera is eliminated by adsorption with 1-100 microM dynorphin-17 whereas immunostaining with enkephalin antisera is eliminated by adsorption with 1… CONTINUE READING