Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Δ9-THC and anandamide 1 Published on the World Wide Web on 18 January 2000. 1

@article{Houser2000DynorphinBA,
  title={Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, $\Delta$9-THC and anandamide
 1
 Published on the World Wide Web on 18 January 2000.
 
 
 1
 
},
  author={Susan J Houser and Michael L. Eads and James P. Embrey and Sandra P. Welch},
  journal={Brain Research},
  year={2000},
  volume={857},
  pages={337-342}
}
The endogenous opioid dynorphin B was evaluated for its role in cannabinoid-induced antinociception. Previous work in our laboratory has shown that the synthetic, bicyclic cannabinoid, CP55,940, induces the release of dynorphin B whilst the naturally occurring cannabinoid, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), releases dynorphin A. The dynorphins contribute in part to the antinociceptive effects of both cannabinoids at the level of the spinal cord. The present study compares dynorphin B… Expand
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