Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.

@article{Arcaya1999DynorphinAI,
  title={Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.},
  author={Jos{\'e} Lu{\'i}s Arcaya and Georgina Cano and Gerber G{\'o}mez and William Maixner and Heberto Su{\'a}rez-Roca},
  journal={European journal of pharmacology},
  year={1999},
  volume={366 1},
  pages={27-34}
}
Dynorphin A-(1-17) has been found to produce spinal antianalgesia and allodynia. Thus, we studied whether dynorphin A-(1-17) modulates substance P release evoked by the C-fiber-selective stimulant capsaicin (1 microM) from trigeminal nucleus caudalis slices. Very low concentrations of dynorphin A-(1-17) (0.01-0.1 nM) strongly facilitated capsaicin-evoked substance P release. This dynorphin A-(1-17) effect was not blocked by the opioid receptor antagonists naloxone (100 nM), beta-funaltrexamine… CONTINUE READING

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