Dynorphin-(1-13), an extraordinarily potent opioid peptide.

@article{Goldstein1979Dynorphin113AE,
  title={Dynorphin-(1-13), an extraordinarily potent opioid peptide.},
  author={Avram Goldstein and Shuko Tachibana and L I Lowney and Michael W. Hunkapiller and Leroy E. Hood},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 12},
  pages={6666-70}
}
We describe the opioid properties of a tridecapeptide, the sequence of which corresponds to the NH2-terminal sequence of dynorphin, a novel porcine pituitary endorphin. It contains [Leu]enkephalin. In the guinea pig ileum longitudinal muscle preparation it is about 700 times more potent than [Leu]enkephalin. Its effects in this tissue are blocked completely by naloxone, but the apparent affinity of naloxone is 1/13th that for blockade of [Leu]enkephalin or normorphine. In the mouse vas deferens… CONTINUE READING

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The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
LeucineNo subtypeLysine
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
LysineNo subtypeLeucine
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
The remarkable enhancement of the potency of [ Leu]enkephalin by the COOH - terminal extension -Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides .
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