Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position.

@article{Koonce1999DyneinMR,
  title={Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position.},
  author={Michael P. Koonce and Jana Koehler and Ralph Neujahr and Jackie M. Schwartz and Irina Tikhonenko and G{\"u}nther Gerisch},
  journal={The EMBO journal},
  year={1999},
  volume={18 23},
  pages={
          6786-92
        }
}
Cytoplasmic dynein is a microtubule-based motor protein responsible for vesicle movement and spindle orientation in eukaryotic cells. We show here that dynein also supports microtubule architecture and determines centrosome position in interphase cells. Overexpression of the motor domain in Dictyostelium leads to a collapse of the interphase microtubule array, forming loose bundles that often enwrap the nucleus. Using green fluorescent protein (GFP)-alpha-tubulin to visualize microtubules in… CONTINUE READING
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